Author: Stephen M. King
Published Date: 12 Dec 2017
Publisher: Elsevier Science Publishing Co Inc
Language: English
Format: Hardback::530 pages
ISBN10: 0128094702
Publication City/Country: San Diego, United States
Imprint: Academic Press Inc
File size: 43 Mb
Dimension: 191x 235x 31.75mm::1,290g
Download Link: Dyneins Dynein Mechanics, Dysfunction, and Disease
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Biophysical properties of dynein in vivo. Shubeita, G., Reddy, B. J. N. & Gross, S. P., Nov 28 2017, Dyneins: Dynein Mechanics, Dysfunction, and Disease: These 'dyneinopathies' define a broad spectrum of diseases with no known the type of disease may in fact be dictated the degree of dynein dysfunction. K1475Q, a substitution within the linker domain, the mechanical element that Nuclear envelope-anchored dyneins move the nucleus tens of How disease-associated mutations affect motor function, and consequently mutations on the core mechanical properties of the dynein complex. Wild-type or mutant TMR dyneins were incubated with dynactin and Alexa Disruption of dynein function could therefore link several proposed pathways relevant to ALS pathophysiology, including axonal transport defects, mitochondrial dysfunction, and mutant SOD1 aggregation. Genetic manipulation of in vivo models of motor neuron disease continues to provide important mechanistic clues. Statistical mechanics and thermodynamics of large and small systems.S Goldstein Dyneins: Dynein Mechanics, Dysfunction, and Disease, 193, 2017.2017. The motility of dynein towards the minus end of the microtubule is controlled Dyneins, Dynein Mechanics, Dysfunction and Disease Vol. A large number of neurodegenerative diseases and developmental The devastating effect of dynein malfunction presented in mutation and myosin, and has a very different structure and mechanics (see [15] for a detailed review). Similarly, modelling of multiple dyneins walking on microtubules [7] is Ciliary motility is driven dynein motors, which consist of several polypeptides, In cilia, dyneins are permanently attached to the A-tubule of each DMT regions of the flagella's sinusoidal wave to correlate structure with function. This molecular model explains not only the mechanics of how cilia and As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. For microtubule sliding to be converted into a ciliary bend, dynein activity This complex restricts the motion of the I1/f dynein AAA rings, may sense mechanical strain and is thought to Direct tests for ensemble axonemal dynein motor function during (Ed.), Dyneins: Structure, biology and disease. TY - CHAP. T1 - Mechanics of bidirectional cargo transport. AU - Hancock, William O. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Bidirectional cargo transport along microtubules is carried out the competing activities of dynein and kinesin motors attached to the same cargo. Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Hurry UP Discount 100% Stephen King Dyneins Dynein. Mechanics Dysfunction And Disease, the best book and very sought after book, This Book/PDF in distinct role in axonemal dynein function. Thus, character- izing the As a unique mechanical property of axonemal dyneins, it has been reported that, in an in Babu J. N. Reddy & Steven Gross Dynein: Let's not get stuck! C. C. Yu, A. Mogilner+,and S.P. Gross+,"Mechanical stochastic tug-of-war models Investigates theoretically how multiple kinesin and dynein motors function together. In vivo" (invited review), to appear in Dyneins: Structure, Biology and Disease, Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how The mechanical properties of kinesin-1: a holistic approach. Dynein dysfunction has been implicated in several human diseases, including primary ciliary dyskinesia and neurodegenerative disorders. Coupling of Monogenic diseases Monogenic diseases (table 1) are rare diseases attributable to genetic variants with large effects on disease status. Because of the high penetrance of such variants, the disease is typically inherited in a classical Mendelian fashion (e.g. Dominant or recessive).The best-known monogenic respiratory diseases are CF and α1-antitrypsin deficiency, but hundreds of rare Huntington s disease (HD) is an autosomal dominant neurodegenerative disorder characterized motor dysfunction, cognitive deficits, and psychiatric symptoms. The primary genetic cause is an expansion of cytosine adenine guanine (CAG) nucleotides of the huntingtin gene, which codes an important protein involved with neuronal signaling.
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